Kraft K, Steinkamp E, Sachinidis A, Seewald S, Vetter H
Effect of autohemotherapy with ozone on cardiovascular risk factors in patients with mild hypertension
Perfusion. 1998: 11(5): 216-219.
In a randomised, doubleblind, placebo-controlled crossoverstudy, 24 h ambulatory blood pressure and blood pressure load were significantly reduced after a cycle of ten autohemotherapies with ozone, but not after a cycle with placebo (oxygen) (p<0.05). The initial blood pressure level was restored after the end of the therapy within 4 months. Aggregation of thrombocytes was significantly and the malondialdehyde concentration was clearly increased, serum HDL concentration was reduced, and the rate of side effects was higher during the cycle with ozone.
The reduction of blood pressure may be due to an increased oxygen supply of the vascular endothelium, but an activation of the oxidative potential of polymorphonuclear leukocytes and/or macrophages cannot be excluded. Considering the small reduction of blood pressure, the potentially noxious oxidative mechanisms and the rather high expenses, autohemotherapy with ozone cannot be recommended as a useful alternative to pharmacological treatment of patients with mild hypertension.
Cardiovascular and Metabolic Effects Caused by Autologous Blood Treatment in Combination with Ozone (GEBO) [ Details ]