Histamine release from rat peritoneal mast cells...: Abstract

	Karl und Veronica Carstens-Stiftung A Foundation for the Promotion and Support of Complementary Medicine

	Harisch G, Kretschmer M Histamine release from rat peritoneal mast cells after oral doses of homeopathically prepared minerals and sodium cromoglycate J Appl Nutrition. 1989: 41: 45-49.
Abstract	Recent results have shown that small amounts of zinc ions influence the histamine release from rat peritoneal mast cells. Therefore the effects of homeopathic zinc preparations were investigated. These effects were compared with those of the homeopathic preparations Sulfur, Silicea, Calcium Carbonicum and with the antiallergic drug disodium cromoglycate (DSCG). All preparations were given orally to adult rats in lactose tablets for 7 d. The histamine release of isolated, non-stimulated mast cells increased in rats given 26 µg zinc/d (Zincum D4) and 260 ng zinc/d (Zincum D6) compared with placebo; with 2.6 ng zinc/d (Zincum D8) the effect was not so pronounced. With Sulfur the increase was most prominent after doses of 0.26 pg/d (D12). For Silicea and Calcium Carbonicum, histamine release increased most with D6 preparations (260 ng/d). Doses of 1.0 mg or 0.01 mg DSCG depressed the histamine release, while 0.001 mg DSCG proved to be ineffective in this system. These novel low-dose effects of minerals require further exploration.

Project	Published from project: Biochemical Basics of Homeopathy [ Details ]

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