Groß MO
Wirkungen konventioneller Verdünnungen und homöopathischer Potenzen der jeweils gleichen Ausgangsstoffe auf Enzymaktivitäten und die Membranstruktur von Peroxisomen der Rattenleber
Dissertation. Hannover; 1994.
To achieve this aim, commercially available lactose-tablets containing different amounts of As2O3and NaCI in form of homeopathic potencies or conventional dilutions were administered daily to groups each consisting of eight healthy male Wistar rats for a total period of seven successive days.
On eighth day, six animals of each group were killed, their livers homogenized and sampled. From these liver homogenates several enzymes and membrane polypeptides were isolated, purified and subsequently analyzed by use of biochemical methods.
The following parameters have been considered in detail:
- Urate-oxidase (EC 1.7.3.3) and Catalase (EC 1.11.1.6) as enzymes of peroxisomal origin
- Acid Phosphatase (EC 3.1.3.2) and N-Acetylic-ß-DGlucosaminidase (EC 3.2.1.52) as lysosomal enzymes
- Cytochrome c-Oxidase (EC 1.9.3.1) as an enzyme originating from mitochondria portion of PMP 70 relative to the peroxisomal membrane fraction
Statistical analysis of the data obtained has revealed disparate effects of potencies and their corresponding dilutions with respect to the various parameters, i.e. enzyme activities and composition of the peroxisomal membrane.
Furthermore, the results point to the existence of particular dose-effect-relations for either potencies and dilutions, which were marked by a maximum effect observed for the D8 and 10-8. Regarding the small amount of obtainable PMP, it was necessary to pool samples, and thus, the effects on membrane composition were not evaluated statistically.
The concluding discussion reflects the results obtained and provides a perspective for future basic research in the field of homeopathy.
Biochemical Basics of Homeopathy [ Details ]