Bertelsmann D
Wirkung kleinster Dosen auf Iysosomale Hydrolasen der Rattenleber
Dissertation. Hannover; 1990.
The investigated substances are potencies of Arsenicum album, Ferrum phosphoricum, Zincum aceticum, Kalium cyanatum as well as Adrenalinum and Histaminum hydrochloricum.
Experiments were carried out using homoeopathically pretreated animals. This was the only difference to common biochemical procedures. The active substances were administered to rats over a period of seven days (Zincum aceticum five days). Every group to be tested included six animals (Zincum aceticum five animals).
The lysosomal parameters were N-acetyl-ß-D-glucosaminidase, ß-D-galactosidase and ß-D-xylosidase (ß-D-xylosidase only in connection with Arsenicum album, Zincum aceticum and Histaminum hydrochloricum pretreatment) as well as lysosomal proteases. In the Arsenicum album series of experiments in addition activity of glyceraldehyde-3phosphate-dehydrogenase and NADPH-cytochromeP450-reductase as well as oxygen consumption of mitochondria by means of polarography were measured.
A previous experiment deals with chronobiological and weight dependencies of the lysosomal parameters.
The influence on the parameters by the substances used are described, compared with the results of the placebo groups, and discussed.
The results of the experiments were as follows:
1. In a comparison made with rats weighing between 60 and 350 g, 180 g rats show maximal lysosomal activities. The measured lysosomal glycosidases are more active at 9.00 a.m. than at 6.00 p.m. The lysosomal proteases show an inverse behaviour to the glycosidases.
2. Arsenicum album potencies influence N-acetyl-ß-D-glucosaminidase and lysosomal proteases in a parallel manner and show maximal inhibition at D12. ß-D-galactosidase and ß-D-xylosidase remain unaffected by Arsenicum album potencies. The accompanying estimations of parameters of other compartments do not show any analogies to the effects on the lysosomal enzymes.
3. Ferrum phosphoricum potencies influence P-Dgalactosidase and lysosomal proteases in a parallel manner and show maximal activation at D6/D8. Nacetyl-ß-D-glucosaminidase is unaffected by Ferrum phosphoricum potencies.
4. Zincum aceticum D6 inhibits, D200 activates ß-D-xylosidase. All employed Zincum aceticum potencies inhibit lysosomal proteases. On N-acetyl-ß-Dglucosaminidase and ß-D-galactosidase there are no obvious effects from Zincum aceticum potencies.
5. Kalium cyanatum potencies obviously do not affect the measured lysosomal enzymes.
6. Adrenalinum potencies do not influence the measured lysosomal enzymes.
7. Histaminum hydrochloricum potencies do not affect the measured lysosomal enzymes.
Biochemical Basics of Homeopathy [ Details ]