Cardiovascular and Metabolic Effects Caused by Autologous
Blood Treatment in Combination with Ozone (GEBO)
by Elli Stenkamp, Ambulanz
für Naturheilverfahren, Medizinische Universitäts-Poliklinik
Universität Bonn
07/93 - 03/94
Does autologuos blood treatment in combination with ozon decrease blood presure in volunteers suffering from mild hypertension? Are there any effects on the metabolism of lipids, aggregation of thrombocytes or are there other laboratory parameters?
Methods
100 ml blood taken from the right cubital vein was mixed with gas. Before the process sodium citrate was added to inhibit clotting of the blood. Two treatment were conducted on the volunteer group. One treatment using a gas mixture of 2000 g with 50 ml oxygen. The other using 50 ml pure oxygen. After both procedures blood was reinjected. Each procedure was repeated ten times during the course of five to six weeks. This was defined as one therapy cycle.
Design
The trial was randomized, double-blind placebo-controlled and was carried out using a crossover design. Volunteers with a diastolic blood-pressure of more than 85 mm Hg between 6 a.m. and 10 p.m. were included. Blood pressure was measured over a 24 hour period. Secondly, the diastolic sphygmomanometrical blood pressure had to be 90-104 mm Hg after sitting for five minutes. The systolic sphygmomanometrical under the same conditions had to be less than 180 mm Hg.
Each volunteer had two therapy cycles. One cycle with the "ozone-treatment", the other with "oxygen". Between the two cycles a treatment-free-interval of four months was required. Within this four-months-period blood pressure was taken as well as blood samples. Additional antihypertensive drugs were restricted. Blood pressure was controlled on an outpatient basis via the 24-hour-measurement. 17 volunteers were included and 14 (five females and nine males) completed all therapy cycles and were evaluated.
Results
24-hour-blood pressure measurements showed a small decrease of diastolic and systolic blood-pressure. under both treatments. A significant decrease was only observed after the ozone-treatment.
 
The blood pressure load decreased significantly after blood treatment with ozone. Here the diastolic blood pressure load decreased by 11.9% and the systolic by 8.5%. After the oxygen-treatment the diastolic blood pressure load decreased by 3.6% and the systolic by only 1%. The Heart rate remained constant. The blood pressure measurements indicated that treatments have the same tendency. A comparison of the observed changes within the two treatment forms did not show any significant difference. concerning aggregation of the thrombocytes, the ozone treatment showed negative effects.
There was a significant increase in this aggregation. After ozone-treatment an increased coagulation following blood reinfusion was observed. The lipid metabolism showed the following changes: The correlation of total cholesterol towards HDL-Cholesterol increased during the course of ozone-treatment. During the course of oxygen treatment there was a significant decrease of this cholesterol index. The HDL-Cholesterol decreased significantly under ozone-treatment and increased under oxygen-treatment. The standard laboratory parameters were all within range with one exception. GTP showed a significant increase during the course of ozone-treatment.
Discussion
After autologous blood treatment in combination with ozone (p<0.005) the diastolic and the systolic blood pressure showed a slight but significant decrease in the group of volunteers suffering from mild hypertension. The working mechanism and duration of this decrease is unknown. Concerning the negative effects on thrombocyte aggregation and lipid metabolism patients have to be examined carefully for those parameters before treated with "ozone".
Effect of autohemotherapy with ozone on cardiovascular risk factors in patients with mild hypertension
Perfusion. 1998: 11(5): 216-219. [ Abstract ]
Stenkamp E
Kardiovaskuläre und metabolische Effekte der großen Eigenblutbehandlung mit Ozon (GEBO)
In: Albrecht H, Frühwald M, eds. Jahrbuch der Karl und Veronica Carstens-Stiftung, Band 1 (1994). Stuttgart: Hippokrates; 1995: 104-110.
Stenkamp E
Kardiovaskuläre und metabolische Effekte der großen Eigenblutbehandlung mit Ozon
Dissertation. Stuttgart: Hippokrates; 1998. edition forschung.
info@carstens-stiftung.de